Sepsis is a common and frequently fatal condition characterized by a dysregulated host response to infection and organ dysfunction . This means that the body injures its own tissues and organs in response to an infection. Septic shock is a subset of sepsis identified by persisting hypotension, despite sufficient fluid resuscitation where circulatory and cellular/metabolic abnormalities greatly increase mortality .
A devastating and potentially lethal condition, sepsis is one of the leading causes of patient death in the intensive care unit (ICU) of hospitals in the United States . Accounting for as many deaths as acute myocardial infarction, sepsis is likely to increase substantially in incidence as the population ages  . Current sepsis management options consist of early goal-directed resuscitation, antibiotic therapy, glycemic control, and recombinant activated protein C for patients with severe sepsis and high risk for death by clinical assessment . Infectious etiologies, such as sepsis and pneumonia, are leading causes of acute respiratory distress syndrome (ARDS) . Sepsis is known to have the highest risk of progression to ARDS .